A master's thesis at the College of Medicine, University of Basrah discussed the determination of the polymorphism and concentration of TNF-alpha and interleukin-6 among patients with acute coronary syndrome in Basrah province. The research presented by the student Sally Abdul Rahim Al-Hamrani aims to study and determine the polymorphism and the concentration of TNF-alpha and interleukin-6 among patients with acute coronary syndrome in Basrah governorate. Where the study was able to review the medical history of some patients and conduct clinical examinations. Then he asked for a routine blood count, blood biochemistry, and ECG to be performed and reviewed by expert cardiologists according to electrocardiogram and serum troponin changes. High section and patients with unstable angina pectoris. This study showed very significant differences in the levels of interleukin-6 and TNF-alpha in patients with acute coronary syndrome. The research concluded that interleukin-6 and tumor necrosis factor-alpha is a good indicator not only of acute coronary syndrome, but also a good indicator of the severity of the disease and the possibility of complications.